E11 Bio - Research Associate, In vivo circuit mapping
Convergent Research
Alameda, CA, USA · Alameda, CA, USA · United States
Posted on Feb 21, 2025
E11 Bio is on a mission to advance connectomics towards whole brain scale for humans and other mammals. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a radical technology platform for scalable mammalian brain mapping. E11 Bio is a non-profit Convergent Research focused research organization located in Alameda, California, pursuing blue-skies neuroscience research yet operating like a nimble, tight-knit start-up. Read our technology roadmap .
E11 is seeking a circuit mapping research assistant to help engineer viral and cellular labels for a moonshot effort making whole-brain connectomics feasible in humans and mice to revolutionize neuroscience and medicine.
Your primary mission as a RA in circuit mapping is to execute on and optimize our in vivo barcode delivery, the heart of E11's technology stack.
About The Role
In your first month, you’ll shadow and work with our lead barcoding scientist on ongoing experiments, learning the why and the how of our cellular labeling approaches. This includes our cloning workflow, our outsourced AAV prep, and the organization of our in vivo work. You will launch your first labeling experiments with the help of our in vivo surgeon and lead scientist, and become familiar with E11’s cross-functional teams.
By 2 months, you’ll have imaged and communicated out the first round of results. You’ll have run at least 2 in vivo experiments from start to finish with the guidance of one of our scientists, and you’ll understand and maintain the molecular & viral reagents required to run them. In collaboration with our lead barcoding scientist, you’ll define a project expanding our ability to label and read out barcoded neural circuits.
At the 3 month mark, you will be routinely managing coordination of circuit labeling and hand-offs to other team members. You’ll be streamlining experiment execution and seeking ways to improve the process. You’ll know our genetic and viral tools backwards and forwards, and started implementing your research plan.
And You
You want a chance to do your best work alongside people who will inspire you and whom you’ll be excited to spend long days with.
You have experience or interest with mouse genetics and/or in vivo viral labeling of neural circuits, and are excited to add basic Python and command line usage to your skillset.
You have experience collaborating on time-sensitive projects involving large numbers of experimental conditions, often with overlapping timecourses. Bonus points for experience collaborating in a team structure across multiple projects.
We Offer
E11 Bio, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other basis protected by applicable local, state, or federal laws or prohibited by Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.
E11 is seeking a circuit mapping research assistant to help engineer viral and cellular labels for a moonshot effort making whole-brain connectomics feasible in humans and mice to revolutionize neuroscience and medicine.
Your primary mission as a RA in circuit mapping is to execute on and optimize our in vivo barcode delivery, the heart of E11's technology stack.
About The Role
In your first month, you’ll shadow and work with our lead barcoding scientist on ongoing experiments, learning the why and the how of our cellular labeling approaches. This includes our cloning workflow, our outsourced AAV prep, and the organization of our in vivo work. You will launch your first labeling experiments with the help of our in vivo surgeon and lead scientist, and become familiar with E11’s cross-functional teams.
By 2 months, you’ll have imaged and communicated out the first round of results. You’ll have run at least 2 in vivo experiments from start to finish with the guidance of one of our scientists, and you’ll understand and maintain the molecular & viral reagents required to run them. In collaboration with our lead barcoding scientist, you’ll define a project expanding our ability to label and read out barcoded neural circuits.
At the 3 month mark, you will be routinely managing coordination of circuit labeling and hand-offs to other team members. You’ll be streamlining experiment execution and seeking ways to improve the process. You’ll know our genetic and viral tools backwards and forwards, and started implementing your research plan.
And You
You want a chance to do your best work alongside people who will inspire you and whom you’ll be excited to spend long days with.
You have experience or interest with mouse genetics and/or in vivo viral labeling of neural circuits, and are excited to add basic Python and command line usage to your skillset.
You have experience collaborating on time-sensitive projects involving large numbers of experimental conditions, often with overlapping timecourses. Bonus points for experience collaborating in a team structure across multiple projects.
We Offer
- An opportunity to help change the world and work with some of the most talented and collaborative experts across scientific fields.
- Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
- Generous time off + paid holidays.
- Wellness allowance for fitness and wellness activities.
E11 Bio, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other basis protected by applicable local, state, or federal laws or prohibited by Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.