Watertown, MA, USA
Posted on Friday, May 19, 2023
Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.New career opportunitiesMembers of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals. Responsibilities
- Design and synthesize novel compounds that can be functionalized with NHS-ester chemistry to conjugate to biomolecules
- Design synthesis steps to allow precise positioning of isotopic substitutes for carbon, nitrogen and/or hydrogen
- Develop protocols and setup equipment for compound purification
- Perform conjugation of biomolecules with compounds
- Analyze and present on compound purity and conjugation rate to team
- Lead all chemistry-related projects across organization
- Create or maintain relationships with external companies and stakeholders related to compound synthesis or distribution
- Collaborate with leadership and team members to achieve platform goals
- Manage and train others on research methodology
- Collaborate with hardware and software engineers
- Define new directions for technology development in collaboration with leadership
- Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others
- 5-10 Years post-PhD experience in compound synthesis
- Passion for breaking barriers in chemistry
- PhD in biochemistry or chemistry
- Demonstrated excellence in team leadership
- Over 4 years of synthesis experience involving isotopes.
- Understanding of purification techniques
- Creative thinking and problem-solving skills
- Highly organized with attention to detail
- Strong quantitative and analytical skills
- Effective communicator to experts outside of the chemistry field
- Ability to set priorities and meet deadlines
- Ability to adapt to changing projects and goals
- You are passionate about science and technology and are eager to work in a team environment.
- You love learning new techniques, new technologies, and new concepts.
- You want an environment that will support your future plans as a scientist or engineer.
- You are committed to open science ideas and want to see your work disseminated broadly
- An opportunity to change the world and work with some of the smartest and the most talented experts from different fields
- Tuition reimbursement
- Excellent medical, dental, and vision insurance through a PPO plan; parental leave
- Generous time off + paid holidays
- Wellness allowance for fitness and wellness activities
See more open positions at convergentresearch.org
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