This is an exciting opportunity to join a fast-paced, growing Focused Research Organization (FRO) startup (currently in stealth). Head of Sequencing will conduct NGS-based experimental research and contribute to novel assay development in a dynamic, interdisciplinary environment. The successful candidate will develop high-throughput workflows and generate datasets from adaptive immune cells. Head of Sequencing will work closely with other top-tier experimental and computational scientists to create groundbreaking new insights into adaptive immunity.

Responsibilities

• Design, plan, and execute NGS-based assays in coordination with interdisciplinary science teams
• Prepare DNA and RNA libraries from immune cells
• Maintain high standards for sequencing quality and throughput by rigorously performing in-house QC checks and remaining current with industry best practices
• Establish and optimize workflows, write and maintain SOPs for NGS assays, maintain sequencer uptime, and manage reagent inventory.
• Contribute to the development of novel NGS and multiomics assays and research, inclusive of experimental design
• Collaborate effectively with computational, molecular biology, and translational researchers
• Oversee junior research staff
• Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others
  
  
  

Key Qualifications

• PhD in biomedical engineering, genetics, immunology or related field that relies on next-generation sequencing applications
• 2-3 years or more of postdoctoral or industry experience, or equivalent
• High proficiency with nucleic acid preparation from adaptive immune cells
• Proven track record of custom library-preparation development for next-generation sequencing
• Expertise with **AIRR-seq / BCR-seq**, scRNA-seq, and other NGS approaches
• Strong organizational, time management, and communication skills
  
  
  

Advanced Qualifications (experience in the following is preferred, but not required)

• Experience with single-cell multiomics techniques (eg, CITE-seq, LIBRA-seq), long-reads, and/or proteomic antibody sequencing (Ab-seq). (strongly preferred)
• Familiarity with diverse next-generation sequencing technologies such as Pacific Biosciences, Oxford Nanopore, and/or Ion Torrent
• Familiarity with diverse microfluidics, microwell, and microfluidics-free platforms
• Experience with liquid handling automation for sequencing library preparation
• Proficiency in custom protocol development
• Experience with sequencing and/or multi omic assay development
• Competence in R and/or Python (Scanpy, Seurat)
• Management experience (inclusive of research assistants or graduate students)
  
  
  

We Offer

• Competitive compensation: $100,000 - $140,000 a year (salary commensurate with experience)
• Excellent medical, dental, and vision insurance
• Generous time off + paid holidays
• A supportive environment to learn and develop new skills
• An opportunity to participate in high-impact, fast-paced, cutting-edge, collaborative team science; contribute to curing disease; and work with leading experts from different fields
• Exciting location in the Soho area of Manhattan