Senior Research Chemist
convergentresearch.org
Watertown, MA, USA
Posted on Friday, July 26, 2024
Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.
Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.
How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org .
New career opportunities
Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.
Summary Of Position
We are looking for an individual contributor who has experience modifying and functionalizing small molecules for protein modifications and/or degradation. This position will involve the investigation and development of mass tags for proteomic analysis. The successful candidate will work in a team environment with other scientists. In order to be seriously considered for this position, we require a cover letter as part of the candidate’s application.
Responsibilities
We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.
Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.
How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org .
New career opportunities
Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.
Summary Of Position
We are looking for an individual contributor who has experience modifying and functionalizing small molecules for protein modifications and/or degradation. This position will involve the investigation and development of mass tags for proteomic analysis. The successful candidate will work in a team environment with other scientists. In order to be seriously considered for this position, we require a cover letter as part of the candidate’s application.
Responsibilities
- Design and synthesize small molecules for protein modification.
- Define new directions for technology development that can unlock new testable hypotheses.
- Collaborate with other scientists to use machine learning and other computational approaches to learn principles for mass tag design.
- Mentor scientists and research associates.
- Prepare internal reports and manuscripts as well as present results at internal or external scientific meetings as appropriate.
- Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.
- Other duties as assigned.
- PhD in Chemistry or Chemical Biology, or related field.
- Experience in synthesizing small molecules for protein modification.
- Strong quantitative and analytical skills, with a proclivity for reasoning from first principles.
- Highly motivated and organized researcher with strong analytical and coding skills.
- Experience with mass spectrometry proteomics data analysis.
- Experience working with isotopes of carbon, nitrogen, oxygen, and hydrogen.
- An opportunity to change the world and work with some of the smartest and the most talented experts from different fields.
- Tuition reimbursement.
- Excellent medical, dental, and vision insurance through a PPO plan; parental leave; wellness allowance.
- Generous time off + paid holidays.
We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.